Artificial intelligence continues to reshape the venture capital landscape, with investors increasing their commitment to startups building the technologies behind the next wave of enterprise innovation.
One of the latest examples is Chemistry Ventures, which is raising $500 million for its second fund, according to a recent SEC filing. The new fund marks a significant step forward for the venture firm just two years after its launch and reflects sustained investor confidence in early-stage AI companies.
Expanding Investment in Enterprise AI
Chemistry Ventures was founded in 2024 by Mark Goldberg, Ethan Kurzweil, and Kristina Shen, three experienced venture capitalists who previously held leadership roles at Index Ventures, Bessemer Venture Partners, and Andreessen Horowitz (a16z).
The firm launched with a $350 million debut fund focused on early-stage startups developing artificial intelligence technologies, from foundational infrastructure to enterprise software applications.
According to reports, the second fund has already attracted strong investor demand and is expected to close soon, highlighting continued momentum in AI-focused venture investing.
Building the Next Generation of AI Companies
Since launching, Chemistry Ventures has backed several fast-growing AI startups across different segments of the market.
Its portfolio includes companies such as Granola, Decagon, Persona, Serval, and Nova Intelligence, reflecting the firm’s focus on businesses building practical AI products and enterprise technologies.
Rather than concentrating on a single category, Chemistry invests across the broader AI ecosystem, supporting startups developing infrastructure, developer tools, and applications designed for business use.
Experience From Leading Venture Firms
The firm’s leadership team brings decades of combined experience investing in some of the technology industry’s fastest-growing companies.
Before co-founding Chemistry Ventures, Mark Goldberg was a partner at Index Ventures, Ethan Kurzweil spent years investing at Bessemer Venture Partners, and Kristina Shen was a general partner at Andreessen Horowitz.
Their goal was to combine the investment expertise gained at major venture firms while creating a focused platform dedicated to supporting ambitious founders building AI-first businesses.
AI Remains a Priority for Venture Capital
The new fundraising effort comes as venture capital firms continue allocating significant amounts of capital to artificial intelligence startups.
Growing enterprise adoption, rapid advances in foundation models, and increasing demand for AI-powered software have strengthened investor interest across nearly every layer of the AI ecosystem.
For firms like Chemistry Ventures, this environment presents an opportunity to identify and support early-stage companies that could become the next generation of enterprise technology leaders.
As competition among AI startups continues to intensify, access to experienced investors and long-term capital is expected to remain a key advantage for founders building products in one of the industry’s fastest-moving sectors.